Nootropic Activity of Zingiber Officinale in Albino Mice: A Behavioral and Neurochemical Approach
نویسندگان
چکیده
Acetone extract of Z. oficinale (AEZ) possessing anti-5HT effect which can be related to antagonism of 5HT3 receptors. 5HT3 receptor antagonists improve basal performance in rhodent and primate tests of cognition and inhibit the cognitive impairments.Material & methods: Spontaneous alteration task paradigm using Y-maze, transfer latency on elevated plus maze, estimation of brain acetylcholinoesterase activity, passive avoidance paradigm and transfer latency on rectangular maze were used as models. Piracetam 200mg/kg p.o. was used as standard. Results: (AEZ) (200mg/kg p.o.) significantly reversed scopolamine induced reduction in spontaneous alteration in behaviour (SAB) and step down latency (SDL) and increase in transfer latency, acetylcholinoesterase (AChE) activity , stepdown error(SDE) and time spent in shock zone(TSZ).Discussion: Central cholinergic system plays an important role in learning and memory. 5HT3 receptor mediates inhibition of acetyl choline release in cortical tissue. (AEZ) is a 5HT3 receptor antagonist. So, it might increase the release of acetylcholine to act as memory enhancer.Conclusion: AEZ is found to be effective in improving both spatial working memory and long term memory.
منابع مشابه
Hepatoprotective potential of aqueous extract of Zingiber officinale leaves using CCl4 induced model
The hepatoprotective activity of crude aqueous extract of Zingiber officinale leaves (ZOL), Zingiberacae, was evaluated, using CCl4 induced hepatic damage in male Wistar albino rats. Various biochemical parameters like serum glutamic pyruvate transaminase (SGPT), serum glutamic oxaloacetate transaminase (SGOT) and total bilirubin were studied. The aqueous ZOL extract afforded significant protec...
متن کاملAuthor's response to reviews Title:Anti-emetic mechanisms of Zingiber officinale against cisplatin induced emesis in the pigeon; behavioral and neurochemical correlates Authors:
متن کامل
Effects of Sophora alopecuroides L., Zingiber officinale Rosc. and Melissa officinalis L. in Formalin and Straub Tail Tests
Background: S. alopecuroides, Z. officinale and M. officinalis are used traditionally in the treatment of pain. Objective: To evaluate the plants effects in the rat formalin test and their activity on the opioid receptors. Methods: Each rat was placed individually in a cage for 30 min to get acclimated. Then 0.05 mL of 10% formalin was injected subcutaneously into the dorsal surface of the r...
متن کاملA Study on the Effect of Zingiber Officinale Hydroalcoholic Extract on Plasmodium berghei in Infected Mice: An Experimental Study
Background and Objectives: Considering the resistance of the Plasmodium parasite (the causative agent of Malaria) to antimalarial drugs, it is essential to find an alternative medicine for treating patients. Therefore, the present study aimed to investigate the antimalarial effect of Zingiber Officinale hydroalcoholic extract on mice infected with Plasmodium berghei. Materials and Methods: In ...
متن کاملAnxiolytic effects of the extracts of Zingiber officinale in mice
Zingiber officinale belonging to Zingiberaceae family is used worldwide as a cooking spice, condiment and herbal remedy. This study was taken up to investigate the anxiolytic activity of alcohol and water extracts of the rhizomes of Zingiber officinale.in mice, by behavioral tests like elevated plus maze (EPM) and open field test (OFT) which will serve as the basis for assessing anxiolytic effe...
متن کامل